The biggest real distinction between AWS Amplify and Medplum is straightforward: AWS Amplify is aimed at Mobile, Teams, whereas Medplum targets Healthcare startups building EHR or patient-facing apps on FHIR with modern tooling. AWS Amplify sits at freemium with a paid tier from $15/month, enterprise plan available and carries low lock-in, while Medplum sits at freemium with paid upgrades and carries low lock-in. AWS Amplify is a fit when you need mobile, teams β typical scenarios include mvp/prototyping speed. Medplum is aimed at healthcare startups building ehr or patient-facing apps on fhir with modern tooling, with workloads like open-source fhir-native ehr backend for digital health teams as the common case. The honest trade-off: AWS Amplify is explicitly not for complex custom business logic; Medplum is not intended for non-healthcare projects or teams that can't invest in learning fhir. Neither tool is a drop-in replacement for the other in every scenario β the choice should track your constraints on budget, lock-in, and target workload rather than general popularity.
Quick take
AWS Amplify is for mobile, teams; Medplum is for healthcare startups building ehr or patient-facing; decide based on which workload you actually run.
Choose AWS Amplify if your primary workload is mobile, teams and the free tier plus $15/month paid tier fits your budget.
βMVP/prototyping speed
βMobile apps needing ready backend
βFaster time-to-market vs. building from scratch
Not for: Complex custom business logic
Choose Medplum whenβ¦
Choose Medplum if your primary workload is healthcare startups building ehr or patient-facing apps on fhir with modern tooling and low switching cost matters.
βOpen-source FHIR-native EHR platform
βHIPAA and SOC2 tooling built in
βSolid developer experience and docs
βSelf-host or managed cloud options
Not for: Non-healthcare projects or teams that can't invest in learning FHIR
Common use cases
AWS Amplify
βMVP/prototyping speed
βMobile apps needing ready backend
βTeams without backend engineers
Medplum
βOpen-source FHIR-native EHR backend for digital health teams
βHIPAA-compliant health record API with Postgres storage
βSOC2-certified FHIR server for US health data applications
βBuilding custom EHR workflows on open-source infrastructure
βAlternative to Aidbox for teams preferring open-source FHIR
Ready to explore?
Check each tool's dedicated page for deeper reviews, setup notes, and pros/cons.
AWS Amplify publishes an entry price of $15/month; Medplum's entry price is not in our data, so a definitive comparison is not possible without a quote from Medplum.
Can I migrate from AWS Amplify to Medplum?
Migrating from AWS Amplify to Medplum is generally feasible because AWS Amplify has low lock-in, so data and configuration are usually portable. Since both tools sit in the same category (Backend-as-a-Service), the conceptual mapping is closer, but you still need to validate feature parity against your specific workload. Plan migration as a project, not a script: inventory integrations, test on non-production workloads, and keep AWS Amplify running in parallel until Medplum is verified.
Which has better developer experience?
Our data gives AWS Amplify and Medplum the same developer experience score (4/5), so neither has a clear edge on DX by that measure. The differentiator is usually how each tool fits your workflow β things like CLI quality, docs, local dev loop, and error messages. The safest call is to pilot both on a representative task and see which one gets out of your way.
Is Medplum a good alternative to AWS Amplify?
Medplum is in the same category as AWS Amplify (Backend-as-a-Service), so it's a reasonable alternative to evaluate. Medplum is aimed at healthcare startups building ehr or patient-facing apps on fhir with modern tooling, while AWS Amplify targets mobile, teams β that difference should drive the switch decision. Note that Medplum is explicitly not for non-healthcare projects or teams that can't invest in learning fhir β if that describes your workload, it's not a viable replacement.
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